低铁与低热量饮食延缓糖尿病肾病的进展

A low iron and low calories diet to slow progression of diabetic nephropathy.

目的探讨低铁与低热量饮食是否能延缓糖尿病肾病的进展。方法以168例Ⅱ型糖尿病肾病患者为研究对象,随机分为两组,对照组予以常规治疗,治疗组在进行同样常规治疗的同时,予低铁、低热量饮食。结果平均随访37±22个月,治疗组患者血清铁水平显著降低,与对照组比较,有显著差异(P<0.01);治疗组血清肌酐189±78μmmol/L,对照组257±115μmmol/L,两组比较,有显著差异(P<0.01)。治疗组有6例患者达到终止随访目标,血红蛋白低于80g/L和或红细胞压积<33%,需进行促红素治疗,占17.6%;对照组有10例达到终止目标,占35.7%,两组比较,有显著差异(P<0.01)。结论低铁饮食治疗能显著降低糖尿病肾病患者铁负荷,配合低热量饮食治疗,能明显延缓糖尿病肾病的进展。

Objective To explore whether a low iron and low calories diet might delay diabetic nephropathy. Method 68 type 2 diabetic nephropathy patients were enrolled into this study, and divided randomizely into two groups： the control subjects employed a routine medication, and study subjects employed the same routine treatment but a low iron and low calories diet. Result Over a mean follow - up interval of 37 ± 22 months, serum ferritin level of study subjects was lower significantly than the controls （P 〈 0.01）, the serum creatinine level of study group was 189 ± 78μmmol/L, while that of the controls was 257 ± 115μmmol/L （P 〈 0.01）. There were 6 termination patients （17.6%） in study subjects and 10 termination patients （35.7%） in controls （P 〈 0.01）. Conclusion Low iron diet can decrease the body iron load significantly , and low iron and low calories diet treatment can slow the progression of diabetic nephropathy significantly.