安珐特治疗慢性乙型肝炎临床效果观察

Clinical efficacy of An-Fa-Te in treatment of chronic hepatitis B

目的探讨治疗乙肝、抗肝纤维化的有效方法。方法对208例慢性乙型肝炎分为两组,两组综合治疗相同,在此基础上,治疗组加用安珐特(复方牛胎肝提取物片)口服治疗。观察患者治疗前后血清Ⅲ型前胶原(PC-Ⅲ)、层粘蛋白(LN)、透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、肝功能等指标的变化及疗效。结果治疗组血清肝纤维化指标(PC-Ⅲ、LN、HA、Ⅳ-C)、丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、血清总胆红素(TBil)、白蛋白(ALB)均有明显改善,与治疗前及对照组比较差异均有高度显著性(P均<0.01),治疗组临床疗效优于对照组(P<0.05)。结论安珐特具有较好的保肝和抗肝组织纤维化作用。

Objective To explore an effective therapeutic regimen for treatment of chronic hepatitis B and for resistance to liver fibrosis. Methods 208 patients with chronic hepatitis B were divided into two groups, a therapeutic group and a control group. The two groups received the same basic combined treatment. Moreover, the therapeutic group was orally given An- Fa- Te （compound fetal cow liver extract） as well. Before and after treatment, the indexes of serum type Ⅲ （PC- Ⅲ ）, hyaluronic （HA）, type Ⅳ collagen （ Ⅳ - C） and hepatic indexes were measured in were measured and the clinical efficacy were observed. Results In the therapeutic group, the serum liver cirrhotic indexes （PC- Ⅲ, LN, HA, and Ⅳ - C）, alanine transaminase （ALT）, aspartase transaminase （AST）, serum total bilirubin （TBiL） and albumin （ALB） were improved after treatment. In comparison to those before treatment and those in the control group, there were statistically significant differenees （ P 〈0. 01）, respeetively.The clinical therapeutic efficacy was better than that of the control group （ P 〈 0.05）. Conclusion An- Fa- Te is more effective in protecting liver function and in resistance to the liver tissue fibrosis.