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新型2,6-二羰酰胺基吡啶类肽的合成及其对卤离子的识别作用 被引量：1

Synthesis and Halide Ion Recognition of a New 2,6-Bis(carbamoyl)pyridine-modified Pseudopeptide
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摘要 合成了一个2,6-二羰酰胺基吡啶桥连的、双丝氨酸酰胺型类肽化合物,其结构经1H NMR、质谱及元素分析证实.通过核磁滴定法研究了该主体与卤离子间的识别相互作用,并计算出相应的络合常数.结果表明,这个类肽能很好地识别卤素负离子,并与其形成1∶1的络合物. A 2, 6-bis（carbamoyl） pyridine-modified diserine Pseudopeptide 1 was synthesized and characterized by ^1H NMR, FAB-MS and elemental analysis. The binding properties of halide anions with 1 were examined using NMR titration and the relative association constants were determined. The result showed that 1 binds well with the halide anions, and forms 1：1 stoichiometric complexes.
作者 范宁娟 郭炜
机构地区 西北农林科技大学生命科学学院 山西大学化学化工学院
出处 《化学研究》 CAS 2005年第4期13-16,共4页 Chemical Research
基金 山西省青年科学基金资助项目(20041006)
关键词 类肽 卤离子识别 核磁滴定 pseudopeptide halide ion recognition NMR titration
分类号 O641.3 [理学—物理化学]
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参考文献17

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二级参考文献17

  • 1GALE P A. Anion receptor chemistry:highlights from 1999[J]. Coord Chem Rev, 2001, 213.. 79-128.
  • 2BEER P D, GALE P A. Anion recognition and sensing: The state of the art and future perspectives[J]. Angew Chem Int Ed Engl, 2001, 40: 486-516.
  • 3KRAL V, SESSLER J L. Molecular recognition via base-pairing and phosphate chelation. Ditopic and tritopic sapphyrin-based receptors for the recognition and transport of nucleotide monophosphates[J]. Tetrahedron, 1995, 51.. 539-554.
  • 4BUHLMANN P, PRETSCH E, BAKKER E. Carrier-Based ion-selective electrodes and bulk optodes. 2. ionophores for potentiometric and optical sensors[J]. Chem Rev, 1998, 98: 1593-1688.
  • 5HUBNER G M, GLUSER J, SEEL G, VOGTLE F. High-Yielding rotaxane synthesis with an anion template[J].Angew Chem Int Ed Engl, 1999, 38: 383-386.
  • 6SZUMMA A, JURCZAK J. A new macrocyclic polylactam-type neutral receptor for anions-structural aspects of anion recognition[J]. Eur JOrgChem, 2001, 66: 4031-4039.
  • 7HOSSAIN M A, LLINARES J M, POWELL D, BOWMAN-JAMES K. Multiple hydrogen bond stabilization of a sandwich complex of sulfate between two macrocyclic tetraamides[J]. Inorg Chem, 2001, 40.. 2936-2937.
  • 8LUECKE H, QUIOCHO F A. High specificity of a phosphate transport protein determined by hydrogen bonds[J].Nature, 1990, 347:402-406.
  • 9SHIOYA T, NISHIZAWA S, TERAMAE N. Enzyme-controlled molecular recognition: selective targeting of trypsin with a substrate-inhibitor supramolecular complex[J]. J Am Chem Soc, 1998, 120:11543-11547.
  • 10RANGANATHAN D, LAKSHMI C, KARKLE I L. Hydrogen-bonded self-Assembled peptide nanotubes from cystine-based macrocyclic bisureas[J]. J Am Chem Soc, 1999, 121: 6103-6107.

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化学研究
2005年 第4期

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