当归芍药散防治高脂血症的实验研究

Preventing and Treating Effect of Danggui Shaoyao Powder on Hyperlipemia in Rabbits

[目的]观察当归芍药散对高脂血症的防治作用并初步探讨其作用机制。[方法]采用饲养法建立家兔高脂血症模型,观察当归芍药散对高脂家兔的血清脂质、肝脏脂质的影响。[结果]当归芍药散可以显著降低高脂血症模型家兔血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、载脂蛋白B100(ApoB100)水平,升高高密度脂蛋白(HDL-C)和载脂蛋白AI(ApoAI)水平,降低肝组织TC、TG,抑制脂质在肝脏的沉积。[结论]当归芍药散防治高脂血症的作用机制可能与以上因素密切相关。

[Objective] To observe the effect of Danggui Shaoyao powder（Angelica sinensis and Hadix paeoniae powder） m preventing and treating hyperlipemia in rabbits and the primary mechanism. [Methods] The hyperlipemia in rabbit was induced by the breeding method. The influence of Danggui Shaoyao powder on the serum and liver lipid in hyperlipemia rabbit was observed. [Results] the Danggui Shaoyao powder could obviously decrease the serum TC, TG, LDL-C, AppoB100 level, increase the HDL-C and ApoA1, decrease the TC and TG of liver tissue and inhibit the liver lipid deposit in hyperlipemia rabbit. [Conclusion] The mechanism of Danggui Shaoyao powder in preventing and treating hyperlipemia maybe closely correlated with above factors.