期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

以RNA为靶标的药物筛选新技术 被引量：1

New techniques for screening drugs targeting at RNAs
下载PDF
导出
作者 吴根福
机构地区 浙江大学生命科学学院
出处 《药学学报》 CAS CSCD 北大核心 2005年第12期1064-1068,共5页 Acta Pharmaceutica Sinica
基金 国家自然科学基金资助项目(30371703).
关键词 核糖核酸 靶标 抗生素 药物筛选 RNA target antibiotics drug screening
分类号 R914 [医药卫生—药物化学]
  • 相关文献

参考文献31

  • 1Xavier KA, Eder PS, Giordano T. RNA as a drug target:methods for biophysical characterization and screening[J]. Trends Biotechnol, 2000,18(8) :349 -356.
  • 2Mischiati C, Jeang KT, Feriotto G, et al. Aromatic polyamidines inhibiting the Tat-induced HIV-1 transcription recognize structured TAR-RNA [ J ].Antisense Nucl Acid Drug Dev , 2001,11(4) :209 -217.
  • 3Hamano T, Murakami S, Takayama K, et al.Characterization of RNA-binding properties of three types of RNA-binding proteins in Anabaena sp. PCC 7120[J]. Cell Mol Biol, 2004,50 (5) :613 - 624.
  • 4Hamy F, Felder ER, Heizmann G, et al. An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication [ J]. Proc Natl Acad Sci USA, 1997,94:3548-3553.
  • 5Furlan RLA, Garrido LM, Brumatti G, et al. A rapid and sensitive method for the screening of DNA intercalating antibiotics [ J ]. Biotechnol Lett, 2002,24(21): 1807 - 1813.
  • 6LiuWR LanXH ZhaoYM.The mechanisms and application of high throughput screening .解放军药学学报,2003,19(1):63-66.
  • 7Filikov AV, Mohan V, Vickers TA, et al. Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR [J]. J Comput Aided Mol Des,2000,14(6) :593 -610.
  • 8Mci HY, Cui M, Heldsinger A, et al. Inhibitors of protein-RNA complexation that target the RNA: specific recognition of HIV-1 TAR RNA by small organic molecules [ J ]. Biochemistry, 1998,37 ( 40 ): 14204 -14212.
  • 9Liu JW, Feldman PA, Lippy JS, et al. A scintillation proximity assay for RNA detection [ J ]. Anal Biochem,2001,289 (2) :239 - 245.
  • 10Hamasaki K, Rando RR. A high-throughput fluorescence screen to monitor the specific binding of antagonists to RNA targets [J]. Anal Biochem, 1998,261(2):183 -190.

二级参考文献41

  • 1Morand KL, Bara TM, Regg B, et al. Techniques for increasing the throughput of flow injection mass spectrometry [J]. Anal Chem. , 2001,73 (2): 247 -252.
  • 2Strege MA. Hydrophilic interaction chromatographyelectrospray mass spectrometry analysis of polar compounds for natural product drug discovery [J]. Anal Chem, 1998,70(13) :2439 - 2445.
  • 3Lane SJ, Pipe A. Unambiguous bead decoding by microelectrospray capillary electrochromatography tandem mass spectrometry of dansylated secondary amine tags from encoded combinatorial organic synthesis [J]. Rapid Commun Mass Spectrom, 1998,12 (11): 667 - 6
  • 4Dunayevskiy YM, Vouros P, Wintner EA, et al.Application of capillary electrophoresis-electrospray ionization mass spectrometry in the determination of molecular diversity [J]. Proc Natl Acad Sci USA, 1996,93(12) :6152 -6157.
  • 5Sjoberg JR, Markides KE. New supercritical fluid chromatography interface probe for electrospray and atmospheric pressure chemical ionization mass spectrometry [J]. J Chromatogr A, 1997,785 (1 - 2):101 -110.
  • 6Sjoberg JR, Markides KE. Capillary column supercritical fluid chromatography atmospheric pressure ionization mass spectrometry interface performance of atmospheric pressure chemical ionization and electrospray ionization [J]. J Chromatogr A, 1999,855(1 )
  • 7Shchepinov MS, Chalk R, Southern EM. Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries: Peptides, Proteins and Nucleic Acids-Small Molecule Organic Chemistry Diversity, Collected Papers [C]. International Symposium, 6th, Y
  • 8Dombi KL, Sterner UE, Richert C. Rapidly measuring reactivities of carboxylic acids to generate equireactive building block mixtures: a spectrometric assay [J]. J Comb Chem, 2003,5(1) :45 -60.
  • 9Leister W, Strauss K, Wisnoski D, et al. Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries [J]. J Comb Chem, 2003,5(3) :322-
  • 10Ripka WC, Barker G, Kgakover J. High-throughput purification of compound libraries [J]. Drug Discovery Today, 2001,6(9) :471 -477.

共引文献2

同被引文献6

引证文献1

二级引证文献1

药学学报
2005年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部