鱼腥草注射液质量控制中的谱效学初步探讨

Profile-effect on quality control of Houttuynia cordata injection

Aim To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.Methods Houttuynia cordata injections from six different factories were determined by gas chromatography(GC) and gas chromatography-mass spectra(GC-MS),and GC fingerprints were classified by hierarchical clustering.The anti-inflammatory activity of Houttuynia cordata injections was characterized through the rat pleurisy model induced by carrageenin and the mice ear edema model by dimethylbenzene.Results The anti-inflammatory effect of the injections from the first class factories on the two model was significant,while those from the second class not.(GC-MS) analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl(n-nonyl ketone),decanoylacetaldehyde,lauryl aldehyde,capryl aldehyde,(β-pinene),(βlinalool),(1-nonanol),(4-terpineol),α-terpineol,bornyl acetate, n-decanoic acid and acetic acid,geraniol ester etc.Conclusion There is corresponding relationship between the fingerprint of Houttuynia cordata injections and effect to a certain extent.

Aim To find corresponding relationship between the fingerprint of Houttuynia cordata iujeetions from different factories and their efl）ets. Methods Houttuynia cordata injections from six different factories were determined by gas chromatography （GC） and gas chromatography-mass speetra （OC-MS） , and GC fingerprints were classified by hierarchical clustering. The anti-inflammatory activity of Houttuynia cordata injections was eharacterized through the rat pleurisy model induced by carrageenin and tbe mice ear edema model by dimethylbenzene. Results The anti-inflammatory effect of the injections from the first class factories on the two model was significant, while those from the second class not. GC-MS analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl n-nonyl ketone, decanoylacetaldehyde, lauryl aldehyde, capryl aldehyde, β-pinene, β-1inalool, 1-nonanol, 4-terpineol, α-terpineol, bornyl acetate, n-deeanoic acid and aeetie acid, geraniol ester etc. Conclusion There is corresponding relationship between the fingerprint of Houttuynia cordata injeetins and effect to a certain extent.