肺癌相关肿瘤标志物与支气管-肺感染的关系

The Relationship of Lung Cancer-related Tumor Makers with Bronchi-pulmonary Infection

目的探讨相关肿瘤标志物(tum orm arker,TM s)对肺癌的诊断价值及与支气管-肺感染的关系。方法测定30例肺癌和195例支气管-肺感染病人血清癌胚抗原(CEA)、糖链抗原211(CA 211)、神经元特异性烯醇化酶(N SE)、糖链抗原199(CA 199)、肿瘤特异性生长因子(TSGF)水平,对临床资料进行分析。结果肿瘤组血清CEA、CA 211、CA 199、N SE均明显高于感染组(P<0.01),TSGF两组间无显著差异(P>0.05)。感染组TM s均值低于正常参考值,但有部分病例高于正常参考值。感染组感染控制后TM s无明显下降,死亡病例CA 211水平明显高于存活病例(P<0.01),血清CEA、CA 199、N SE水平在死亡病例与存活病例间无显著差异(P>0.05)。结论支气管-肺感染患者血清TM s无明显增高,对血清TM s增高的仍应注意排除肿瘤。

Objective To explore the utility of lung cancer-related tumor makers （TMs）in the diagnosis of lung cancer and the relationship between tumor makers and bronchi-pulmonary infection. Methods Serum levels of CEA,CA211 ,NSE,CA199 and TGSF were analyzed in 30 patients with lung cancer and in 195 cases with bronchi-pulmonary infection. Results The levels of CEA,CA211,CA199,NSE in lung cancer group were significantly higher than that of infection group（P〈0.01）. There was no significant difference between the two groups in level of TGSF（P〉0.05）. The average value of TMs was lower than the normal value in infection group,but in some cases the levels of TMs was higher than that of the normal value. In infection group,no significant decrease of TMs had been found after the control of infection,the serum level of CA211 was significantly higher in death cases than that of in survive patients （P〈0.01）,there were no significant differences in levels of CEA,CA199,NSE between the two groups（P〉0.05）. Conclusion The levels of TMs had no significantly increased in patients with bronchi-pulmonary infection.