心肌炎患儿血一氧化氮与氧自由基的变化及意义

SERUM NITRIC OXIDE AND OXYGEN FREE RADICAL LEVELS IN CHILDREN WITH MYOCARDITIS

目的探讨血一氧化氮(NO)及氧自由基(OFR)在小儿心肌炎(MC)中的作用及意义。方法检测30例急性心肌炎患儿NO、丙二醛(MDA)及超氧化物歧化酶(SOD)含量,选择18例健康体检者为对照组。结果MC患儿NO、MDA水平明显高于对照组(P<0.01),SOD活性明显低于对照组(P<0.01);MC组于治疗后2周时NO、MDA水平均比治疗前显著下降(P<0.01),SOD活性比治疗前明显升高(P<0.01)。结论NO与OFR参与了心肌炎的发病过程;测定NO、MDA及SOD含量有助于心肌炎患儿的病情评价。SERUM NITRIC OXIDE AND OXYGEN FREE RADICAL LEVELS IN CHILDREN WITH MYOCARDITIS WangHui,Wang Lijin.Department of Pediatrics,The Huainan Second Miner's Hospital,Huainan 232052。

Objective To study the clinical significance of serum nitric oxide（NO） and oxygen free radical（OFR） levels in children with myocarditis（MC）. Methods Serum levels of NO, MDA and SOD in 30 MC cases were measured, 18 healthy subject served as normal controls. Results Serum NO and MDA levels in MC children were significantly higher than those in normal subjects（P〈0.01）. Serum levels of NO and MDA in MC at two weeks after treatment were significantly decreased（P〈0. 05） ; SOD activity of serum in MC groups was significantly lower than that in normal groups（P〈0.01）,but significantly increased at two weeks after treatment. Conclusion The present data suggests that NO and OFR may play an important role in the pathologic process of MC. The serum levels of NO,SOD and MDA were correlated with MC severity.