摘要
NF-κB在机体炎症反应和免疫应答等过程中发挥重要作用。早产和分娩发动中NF-κB的激活,是启动并调节白介素-1、-6-、8,肿瘤坏死因子-α,一氧化氮,前列腺素等细胞因子分泌的关键,其阻滞剂可预防早产,是早产治疗和相关药物研究的新方向。
The nuclear factor kappa B （NF-κB） family play important roles in inflammatory response and immune regulation of human body. The activation of NF-κB in preterm labor and labor initiation is a key to initiate and regulate the secretion of cytokines such as IL-1, IL-6, IL-8 ,TNF-α, NO, PG. NF-κB inhibitor may therefore provide an alternative therapeutic strategy in prevention of preterm delivery and development of new medication for infection-induced preterm labor.
出处
《国外医学（妇幼保健分册）》
2005年第6期358-360,共3页
Foreign Medical Sciences (Section of Maternal and Child Health)
关键词
核因子ΚB
妊娠
早产
分娩发动
nuclear factor kappa B
pregnancy
preterm labor
labor initiationt
