滋养细胞增生与病变恶性程度相关性研究进展

Advances in research on relationship between proliferation of trophoblast cells and the malignancy degree of gestational trophoblastic disease

妊娠滋养细胞肿瘤是一组早期即可出现转移的肿瘤,如何及早、准确的预测此类疾病发展预后受到很多学者的关注。目前,增殖标记物在肿瘤预后的预测方面的意义受到越来越多的重视。该文分析了近几年对K i-67、增殖细胞核抗原、核仁组成区相关嗜银蛋白等3种细胞增殖标记物在滋养细胞疾病中的研究成果,综述其在滋养细胞疾病中增殖程度与病变恶性程度的关系。

Gestational trophoblastic disease is a group of tumors that metastasizes in early stage, how to predict the prognosis of GTD early and accurately has attracted many scholars＇ concern. At present, the predicting role of proliferation markers for prognosis of the tumour has attracted more and more attention. This paper analyzed the studies on three proliferation markers, Ki-67 ,PCNA and AgNOR, in GTD conduted in recent years and reviewed the relationship between proliferation of trophoblast cells and the malignancy degree of GTD.