代谢综合征患者的自主神经功能紊乱

A study on dysfunction of the autonomic nervous system in patients with metabolic syndrome

目的探讨代谢综合征患者是否存在自主神经功能紊乱。方法82例代谢综合征患者和36例健康人用心率变异性(HRV)分析作短时时域和频域检测。结果代谢综合征组的平均心率显著大于健康对照组(81.5±9.7次/分,72.3±8.6次/分,P<0.01),SDNN显著小于健康对照组(98.1±8.6 ms2,138.9±11.5ms2,P<0.01),LF与健康对照组无显著性差异(434.8±415.9 ms2,417.6±404.8 ms2,P>0.05),LF显著小于健康对照组(181.2±126.5 ms2,278.4±198.7 ms2,P<0.05),LF/HF比值显著大于健康对照组(2.4±1.3,1.5±0.9,P<0.01)。结论代谢综合征患者存在自主神经功能紊乱,主要是迷走神经活性显著降低,使自主神经功能指数LF/HF比值显著增大。

Objective： To research whether or not there exists dysfunction of the autonomic nervous system in patients with metabolic syndrome. Methods： 82 patients suffering from metabolic syndrome and 36 normal subjects were examined by the use of short-term time domain and frequency domain measures of heart rate variability （HRV）. Results： The average HR of the metabolic syndrome group was significantly larger than that of the control group （81.5±9.7, 72.3±8.6, P 〈 0.01）, SDNN was significantly less than that of the control group （98.1±8.6 ms^2, 138.9±11.5 ms^2, P 〈 0.01）, LF was similar to that of the control group （434.8±415.9 ms^2, 417.6±404.8 ms^2, P 〉 0.05）, HF was significantly less than that of the control group （181.2±126.5 ms^2, 278.4±198.7 ms^2, P 〈 0.05）, and LF/HF ratio was significantly larger than that of the control group （2.4±1.3 1.5±0.9, P 〈 0.01）, Conclusion： There is dysfunction of the autonomic nervous system in patients with metabolic syndrome, and LF/HF ratio-the sympathovagal function balance index increases significantly owing to the decrease in vagal nervous activity in these patients.