晚期胃癌p16、p53、E-cad基因表达及其临床意义

Expressions of p53,p16 and E-cad proteins in terminal gastric carcinoma and their clinical significance

目的讨论p16、p53以及Ecad基因在晚期胃癌中表达,及其与胃癌分化程度的关系。方法采用免疫组化检测65例晚期胃癌手术标本p16、p53及Ecad基因的表达。结果p53蛋白表达升高、Ecad表达下调与胃癌分化程度关系密切。p16蛋白表达与胃癌分化程度无关。结论p53、Ecad的检测可作为判断胃癌恶性程度的参考指标。

Objective To investigate the expressions their correlations with the grade of differentiation. Methods of p53, p16 and E-cad genes in terminal gastric carcinoma, and The expressions of p53, p16 and E-cad were detected by using iramunohistochemistry in 65 specimens of gastric carcinoma. Results The positive rate of p53 in well-differentiated gastric carcinoma tissues was significantly lower than that in poor-differentiated ones. The positive expression of E-cad was correlated with histological type and degree of defferentiation of gastric carcinoma. No correlation between the expression of p16 and grade of differentiation was observed. Conclusion The abnormal expressions of p53 and E-cad may play an important role in the course and prognosis of gastric carcinoma.