慢性肾衰患者血清脂联素水平及其临床意义的研究

The level and clinical significance of serum adiponectin in CRF patients

目的测定慢性肾衰患者血清脂联素水平,分析其在慢性肾衰患者心血管疾病发生中的意义,以及与年龄、肾功、血红蛋白、白蛋白、血脂的关系。方法慢性肾衰患者64例,分为肾功能不全组32例(A组),肾功能不全合并心血管疾病组32例(B组),正常对照组20例(C组),用ELISA方法测定脂联素,同时测定肾功、血红蛋白、白蛋白、血脂。结果①A和B组血清脂联素水平均明显高于C组,且B组脂联素水平低于A组,差异有统计学意义(P<0.05);②脂联素水平与年龄、总胆固醇、低密度脂蛋白无相关性,与甘油三酯、血红蛋白、白蛋白呈负相关,与肌酐、尿素氮、高密度脂蛋白胆固醇呈正相关。结论在慢性肾衰患者中发生心血管疾病者血清脂联素水平降低;高水平的血清脂联素在慢性肾衰患者中的保护意义尚不明确。

Objective To examine the level of serum adiponectin in patients with chronic renal failure（CRF）, analyze its role in the occurrence of the cardiovascular disease （CVD） in CRF patients and identify the relationship between adiponectin and age, renal function, Hb, ALB and blood lipid. Methods Group A：32 CRF patients without CVD;Group B：32 CRF patients with CVD;Group C：20 people as control group. Adiponectin, renal function, Hb, ALB and blood lipid were measured. Results ①Semm adiponectin levels of A and B were significantly higher than that of group C, and Group B was lower than Group A （ P 〈 0.05）. ②Semm adiponectin levels were not correlated to age, T-ch, LDL, but they were negatively correlated to TG,Hb, ALB and positively related to SCr, BUN, HDC. Conclusion The serum adiponectin lowered in CRF patients complicated with CVD;The protection role of high level adiponectin in CRF patients is not clear.