妊娠期肝内胆汁淤积症240例临床分析

Clinical analysis of 240 cases of intrahepatic cholestasis of pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)对母儿的不良影响。方法回顾性分析我院1997.4-2004.12收治的240例ICP患者的临床资料,对其诊断、治疗和新生儿预后进行分析和总结。结果皮肤瘙痒者占96.67%,黄疸发生率29.17%,胆酸及肝酶升高者达97.5%,早产发生率35%,胎儿窘迫发生率34.17%,剖宫产率74.17%,产后出血占1.67%,围生儿死亡2例占8.3‰。结论ICP对围生儿预后的影响较大,加强胎儿监护和孕妇生化指标的监测、适时终止妊娠可降低围生儿的病死率。

Objective：To explore poor outcomes in the mother and clfild in intrahepatic cholestasis of pregnancy. Methods：240 patients with ICP were studied retrospectively. Results： The percentage of pruritus,jaundice, the increase of TBA and liver enzymes, premature delivery, fetal distress, postpartum hemorrhage, fetal death is 96.67 %, 29.17 %, 97.5 %, 35 %, 34.17 %, 1.67 %, 8.3‰, respectively. Conclusions ： Enhancing hepatic function test and proper treatment may minimiza tire perinatal mortality.