下呼吸道感染患儿血清可溶性SIL－2R和免疫球蛋白IgG_4水平的研究

A study of serum soluble interleukin-2 receptor and immunoglobulin G_4in children with recurrent lower respiratory tract infection

对反复下呼吸道感染患儿的血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）和血清及唾液中免疫球蛋白（ＩｇＧ４）的水平进行了检测。结果表明：反复下呼吸道感染患儿在发病期间其血清可溶性白细胞介素－２受体水平比健康儿童明显升高（Ｐ＜０．０１），而血清及唾液中免疫球蛋白ＩｇＧ４与健康儿童相比明显降低（Ｐ＜０．０５和Ｐ＜０．００５），提示反复下呼吸道感染的小儿存在着细胞和体液免疫紊乱。

Levels of serum soluble interleukin-2 receptor and immunoglobulin G4(both salivary and serum)were measured in 38 children with recurrent lower respiratory tract infection. The results revealed that levels of serum soluble interleukin-2 receptor were elevated during the course of the disease(P <0. 01), while serum and salivary IgG4 levels were lowered significantly as compared with those healthy children. It suggests that there is a T+B cell immunity functional disturbance in children with recurrent lower respiratory tract infection.