加味止嗽汤配合西药治疗咳嗽变异性哮喘60例临床观察

Clinical observation of varied Zhisuo decoction combined western medicine on 60 patients with cough variant asthma

目的观察加味止嗽汤配合西药治疗咳嗽变异性哮喘的临床疗效。方法将100例咳嗽变异性哮喘患者随机分为2组。对照组40例予普米克(布地奈德)气雾剂吸入,每晚睡前1揿(每揿含布地奈德50μg),口服氨茶碱0.1 g,3次/日,氨溴索30 mg,3次/日。治疗组60例在对照组治疗基础上,加服中药加味止嗽汤。2组均7日为1个疗程,2个疗程后统计疗效。结果治疗组治愈率为68.33%,对照组治愈率为45.00%,2组比较有显著性差异(P<0.05)。肺功能[第1秒用力呼气容积(FEV1)和呼气峰流速(PEF))均有改善,治疗前后比较差异有显著性(P<0.05)],治疗后组间比较有显著性差异(P<0.05)。结论加味止嗽汤有明显的止咳作用,中西医结合治疗咳嗽变异性哮喘疗效优于单纯西药治疗。

Objective To observe the clinical effect of varied Zhisuo decoction combined western medicine on patients with cough variant asthma. Methods 100 patients with cough variant asthma were randomly divided into two groups. 40 patients in the control group were given Aminophylline Tablet 0.1 gram and Ambroxo Hydrochloride capsule 30 milligram each time, three times a day and inhaled Budesonide gas apray 50 tJg every night before go to bed. 60 patients in the treatment group were administrated varied Zhisuo decoction in addition to the routine treatment used in the control group. Seven days was a therapeutic course in both group. The cure rate and pulmonary function improvement were observed in both groups. Results The symptoms in both group were improved. There was no significant difference of the total effectiveness rate between the two groups （ P 〉 0.05） but there was a significant difference of the cure rate between the two group （ P 〈 0.05）. The pulmonary function significantly improved after treatment in both group （ P 〈 0.05）. There was a significant difference between the two groups after treatment （ P 〈 0.05）. Conclusion Varied Zhisuo decoction has a definite effect on cough and the therapy of TCM combined western medicine has advantage over pure western therapy.