中期孕胎儿肝脏与骨髓红细胞系统造血的比较研究

COMPARATIVE STUDY ON ERYTHROPOIESIS IN FETAL LIVER AND FETAL BONE MARROW IN PREGNANCY OF SECOND TRIMESTER

采用瑞氏染色、红细胞内外铁染色和受体的放射配体结合分析法,对29例16～28孕周胎儿肝脏与骨髓红细胞系统进行了比较研究.结果发现:(1)贮存铁在正常范围的胎儿的骨髓幼红细胞比例(42.8%)明显低于肝脏(84.4%),其变异系数均明显高于肝脏;(2)24～28周孕的胎儿,其肝脏的红细胞内、外铁均较骨髓为多;(3)骨髓幼红细胞转铁蛋白受体数量及其与配体的亲和力均明显低于肝脏;(4)母体发生缺铁性贫血时,虽然骨髓受体数量明显上升,但亲和力和幼红细胞比例仍低于肝脏.结果提示:28孕周以前,肝脏仍是红系造血的主要器官,骨髓造血的稳定性及代偿能力均受到生理发育的限制.

A comparative study was made on transferrin receptor (TfR) of fetal liver and fetal bone marrow by iron staining and radioligand assay to compare the hematopoetic status in these two important organs in the second trimester of pregnancy. We found that: 1. The erythroblast ratio on the nucleated cells in the fetal bone marrow was lower than that in the liver, and the coeffi-cient of variation of the erythroblast in the fetal bone marrow was higher than that in the liver, although maternal iron status were normal. 2. The amount of the iron storage(hemosiderin and sideroblast) in the liver was higher than that in the bone marrow. 3. Both of the transferrin re ceptor level and its affinity on the erythroblast of fetal bone marrow were lower than those in fe-tal liver even if the mothers were in iron deficiency status. Our results indicate that the fetal liver is the main erythropoietic organ in the second trimester of the pregnancy and has a more stable erythropoietic function than the fetal bone marrow.