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肺癌中S100A4蛋白的表达与意义

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作者 齐瑞雪 徐向英
机构地区 哈尔滨医科大学附属肿瘤医院放疗一科
出处 《实用肿瘤学杂志》 CAS 2005年第6期456-459,共4页 Practical Oncology Journal
基金 黑龙江省教育厅海外学人科研项目资助(1053HQ016)
关键词 肺癌患者 S100A4蛋白 非小细胞肺癌(NSCLC) 分子生物学研究 临床治疗 恶性肿瘤 大细胞癌 表达产物 基因活性 肿瘤细胞
分类号 R734.2 [医药卫生—肿瘤] R378.911 [医药卫生—病原生物学]
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参考文献22

  • 1Mazzuccheli L.Protein S100A4:too long overlooked by pathologists [J].Am J Pathol,2002;1609(1) :7 - 13.
  • 2Rosty C,Ueki T,Argani P,et al.Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation [J].Am J Pathol,2002; 160(1) :45 - 50.
  • 3Donato R.S100:a multigenic family of calcium - modulated proteins of the EF - hand type with intracellular and extracellular functions roles [J].Int J Biochem Cell Biol,2001 ;33(7) :637 - 668.
  • 4Schafer BW,Heizmann CW.The S100 family of EF- hand calciumbinding proteins:functions and pathology [J].Trends Biochem Sci,1996;21:134 - 140.
  • 5Hsieh HL,Schafer BW,Sasaki N,et al.Expression analysis of S100proteis and RAGE in human tumors using tissue microarrays [J].Biochem Biophys Res Commun,2003;307(2):375 - 381.
  • 6Sherbet GV,Lakshmi MS.S100A4 (MTS1) calcium binding protein in cancer growth,invasion and metastasis [J].Anticancer Res,1998; 18(4) :2415 - 2421.
  • 7Taylor S,Herrington S,Prime W,et al.S100A4 (p9Ka) protein in colon carcinoma and liver metastasis:association with carcinoma cells and T - lymphocytes [J].Br J Cancer,2002;86(3) :409 - 416.
  • 8Gribenko AV,Hopper JE,Moakhatadze GI.Molecular characterization and tissue distribution of a novel member of the S100 family of EFhand proteins [J].Biochemistry,2001 ;40(51):15538 - 15548.
  • 9Watanabe Y,Usada N,Minami H,et al.Calvasculin,as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene [J].FEBS Lett,1993;324:51 -55.
  • 10Davies BR,Davies MP,Gibbs FE,et al.Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka,a rat calcium - binding protein,but not with the oncogene EJ- ras - 1 [J].Oncogene,1993;8:999 - 1008.

二级参考文献16

  • 1Ishihara S, Minato K, Hoshino H, et al. The cyclin dependent kinase inhibitor p27 as a prognostic factor in advanced non-small cell lung cancer: its immunohistochemical evaluation using biopsy specimens. Lung cancer,1999,26(3) : 187-194.
  • 2Mazzuccheli L. Protein S100A4: too long overlooked by pathologists? Am J Pathol,2002,160(1) : 7-13.
  • 3Sherbet GV, Lakshmi MS. S100A4(MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Res,1998,18(4A): 2415-2421.
  • 4Cajone F, Sherbet GV. Stathmin is involved in S100A4 mediated regulation of cell cycle progression. Clin Exp Metastasis, 1999,11(10) : 865-871.
  • 5Platt-Higgins AM, Renshaw CA, West CR, et al. Comparison of the metastasis-inducing protein S100A4 (p9Ka) with other prognostic markers in human breast cancer. Int J Cancer,2000,89(1):198-208.
  • 6Davies BR, O' Donnell M, Durkan GC, et al. Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer. J Pathol,2002,196(1): 292-299.
  • 7Rivard N, L'Allemain G, Bartek J, et al. Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts. J Biol Chem,1996,271(31): 18337-18341.
  • 8Esposito V, Baldi A, Luca AD, et al. Prognostic role of the cyclindependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res,1997,57(8) : 3382-3385.
  • 9Ninomiya I, Ohta T, Fushida S, et al. Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinome. Int J Oncol,2001,18(4): 715-720.
  • 10Yonemura Y, Endou Y, Kimura K, et al. Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer. Clin Cancer Res,2001,92(6): 832-838.

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实用肿瘤学杂志
2005年 第6期

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