哮喘患者血嗜酸性粒细胞活性指标的检测

Study on the blood eosinophil activity in asthmatic patients

目的和方法：嗜酸性粒细胞（ＥＣ）是哮喘发病中的重要效应细胞，为研究哮喘患者体内ＥＣ的激活程度，我们选择血清嗜酸细胞阳离子蛋白（ＥＣＰ）浓度和外周血ＥＣ密度作为其活性指标进行检测．结果：哮喘患者外周血低密度（密度＜１．０９０ｋｇ／Ｌ）嗜酸细胞（ＨＥ）（３６．３０±１４．８０）％较正常人（１４．７１±８．２０）％增多（Ｐ＜０．０５）；患者血清ＥＣＰ浓度（１０．７４±７．２２）ｍｇ／Ｌ也高于正常人（６．３９±４．９１）ｍｇ／Ｌ（Ｐ＜０．０５），哮喘患者血ＨＥ百分比与ＥＣＰ浓度呈显著相关（ｒ＝０．４０，Ｐ＜０．０５）．结论：哮喘患者体内ＥＣ激活；

Objective and Methods: Eosinophils are major effect cells in pathogenesis of asthma. To investigate the degree of eosinophil activity in asthmatic patients, we measured serum eosinophil cation protein (ECP) level and peripheral blood eosinophil density. Results: The number of hypodense eosinophils in the blood of asthmatic patients were significantly higher than that in normal subjects [(36.30±14.80) % vs (14.71±8.20)%, P <0.05]. The level of serum ECP increased in parallel to that of hypodense eosinophil percentage (HE%). Conclusion: Eosinophils in asthmatics are activated. The blood HE% and serum ECP level could be considered as parameters indicating the severity of chronic airway inflammation.