脑卒中后抑郁相关因素分析

A Clinical Observation of Related Factors and Treatment of Post-stroke Depression

目的:观察脑卒中后抑郁(post-stroke depression,PSD)与病损部位、吸烟、合并疾病、神经功能缺损程度、社会家庭支持度等因素的相关性,以及心理、药物干预治疗疗效。方法:采用Zung抑郁量表(self-ratingdepression scale,SDS)测评164例脑卒中后抑郁,SDS≥50分确定为抑郁。根据影像学确定病损程度,临床体检结果判定神经功能缺损程度,并用一般情况调查表对患者进行调查。结果:脑卒中后抑郁57例(34.8%),抑郁与病损部位、吸烟、合并疾病、神经功能缺损程度、社会家庭支持度等因素呈正相关(P<0.05),心理及三环类药物治疗后大部分患者有效。结论:病损部位、吸烟、合并疾病、神经功能缺损程度、社会家庭支持度是PSD的相关因素,心理及药物干预有效。

Objective： To observe the relationship of post-stroke depression （PSD） with related factors, such as location of lesion, habit of smoking, complicating diseases, neurological deficits and social support, and to evaluate the effects of both physical and psychological treatments. Method： 164 stroke patients were evaluated by zung＇s self rating depression scale （SDS）. If SDS score≥50 points, the patient was thought as suffering from depression. Lesion location were identified by CT or MRI. Neurological deficits were assessed by physical examination, a self-designed questionnaire was used in this investigation for general conditions of the patients. Results： 57 cases were identified as PSD （34.8%）. The depression had a positive connection to those tested factors （P 〈 0.05）. Psychothereapy and medicine showed good effects on PSD. Conclusions： Location of lesion, habit of smoking, complicating diseases, neurological deficits and social support might be related factors of PSD. Both psychothereapy and medical treatment are effctive.