PEG活化固体超强碱催化合成茴香醇

Synthesis of anisyl alcohol by polyethylene glycol activated solid superbase as catalyst

对甲氧基苯甲醛与甲醛的Cannizzaro反应合成茴香醇工艺进行了改进。采用KF/γ-Al2O3固体超强碱催化剂、PEG为催化活化剂的工艺路线,提高了产物的收率。最佳工艺条件为对甲氧基苯甲醛∶36%甲醛∶KF/γ-Al2O3∶PEG=1.0∶1.5∶0.03∶0.1,反应时间1.5h,反应温度60℃,所得的茴香醇的产率可达71%。催化剂KF/γ-Al2O3具有较高的催化活性,易于回收,可重复使用5次以上。

The synthesis cannizzaro of anisyl alcohol from anisaldehyde and formaldehyde was improved with higher yield by solid superbase （KF/γ- Al2O3） as catalyst and polyethylene glycol as catalytic activator. The yield of anisyl alcohol can reach 71% when the ratio in weight of starting meterials is anisaldehyde ： 36% formaldehyde ： KF/γ- Al2O3 ： polyethylene glycol = 1 ： 1.5 ： 0. 03 ： 0. 1, reaction time 1.5h and reaction temperature 60℃. The catalyst can be recovered and mused for more than five times.