己酮可可碱对不稳定型心绞痛患者血浆纤维蛋白原的影响

Effect of pentoxifylline (PTX) on plasma fibrinogen content in aged patients with unstable angenia pectoris

目的:探讨己酮可可碱对老年不稳定型心绞痛患者血浆纤维蛋白原含量的影响。方法:56例冠心病不稳定型 心绞痛患者被随机分为两组,治疗组予己酮可可碱0．4 mg／d,静脉输入,对照组予前列地尔100μg／d,静脉输入,疗 程20 d。治疗前、后检查心肌缺血相关症状、心电图,同时常规查肝、肾功能,血浆纤维蛋白原浓度,并观察药物不 良反应。结果:治疗组与对照组临床疗效总有效率分别为92．8％,96．4％,无显著差异。两组治疗后血浆纤维蛋白 原浓度较治疗前均显著降低,二组之间亦无显著差异;两组均未发现严重副作用。结论:己酮可可碱改善心肌缺血, 其疗效与前列地尔无显著差别。

Objective： To evaluate the effect of pentoxifylline （PTX） on plasma fibrinogen content in old patients with unstable angenia pectoris. Methods： A total of 56 patients with unstable angenia pectoris （UAP） were randomly divided into two groups. The treatment group were infused by venous with PTX 0.4 g every day, and the control group were infused by venous with PGE 200μg every day for twenty days. Results： After treatment, the total therapeutic effect of treatment group, control group was 92.8%, 96.4% respectively; the therapeutic effect between two groups was no significant difference. The levels of plasma fibrinogen of two groups significantly decreased but there was no significant difference between two groups. There was no serous side effect. Conclusion： Pentoxifylline can improve myocardial ischemia as well as PGE.