高血压所致慢性充血性心力衰竭患者血清sFas水平及临床意义

Serum sFas level in patients with chronic congestive heart failure caused by hypertension and its clinical significance

目的:观察高血压所致慢性充血性心力衰竭(CHF)患者血清sF as浓度的变化并探讨其临床意义。方法:选取高血压所致慢性充血性心力衰竭患者22例,单纯高血压患者19例,正常对照组21例。采用EL ISA法测定血清sF as浓度。结果:①与正常对照组相比,高血压CHF组血清sF as水平显著升高(P<0.01),高血压无CHF组和对照组之间血清sF as的水平变化无统计学意义(P>0.05)。②sF as水平随心功能不全的加重而明显升高,心功能Ⅳ级组患者高于心功能Ⅱ、Ⅲ级组患者(P<0.05)。结论:由高血压所致慢性充血性心力衰竭患者血清凋亡相关因子sF as水平明显升高,细胞凋亡在此类心衰的发病机制中起了重要作用。

Objective： To investigate the serum soluble Fas （sFas） level in patients with chronic congestive heart failure caused by hypertension and its clinical significance. Methods. Our study included 22 patients with chronic congestive heart failure caused by hypertension and 19 patients with simple hypertension ;and 21 normal control subjects. The serum sFas level was measured by enzyme linked immunosorbent assay. Results： The serum sFas level was significantly higher in the patients with heart failure than those in the normal subjects and in the patients with simple hypertension（ P 〈 0. 01 ）. The serum sFas level in the patients with heart failure rised significantly with cardia insufficiency. The serum sFas level in the patients with grade Ⅳ chronic congestive heart failure were higher than those in the patients with grades Ⅱ and Ⅲ （ P 〈 0. 05 ）. Conclusion： The serum sFas level elevates in the patients with chronic congestive heart failure caused by hypertension, which may play an important role in the pathogenesis of chronic congestive heart failure.