磷酸钙类人工骨药物缓释载体治疗慢性骨髓炎

Calcium phosphate artificial bone as a drug delivery system in the treatment of chronic osteomyelitis

目的:探讨磷酸钙类人工骨药物缓释载体一般属性、药物释放动力学及其在慢性骨髓炎治疗中的良好应用价值。资料来源:应用计算机检索Medline数据库1963-01/2005-09的相关文章,检索词为“calciumphosphate,artificialbone,drugdeliverysystem,osteomyelitis”,并限定文章语言种类为English,同时计算机检索CNKI、中国期刊全文数据库的相关文章,限定文章语言种类为中文,检索词为“磷酸钙d人工骨d药物缓释系统d骨髓炎”。资料选择:对资料进行初审,选取实验性研究,然后筛除低水平重复性文章和综述,对剩余文献进行全文阅读。资料提炼:共收集了98篇文章,23篇符合纳入标准,其余75篇均为重复内容。资料综合:对收集的文献按3个部分进行归类,分别介绍羟基磷灰石、磷酸三钙、磷酸钙骨水泥的属性、治疗骨髓炎的应用前景、载体的优缺点和其释药动力学特性。结论:治疗骨髓炎理想的磷酸钙类人工骨载体材料应有合适的生物力学强度、良好的组织相容性、可生物降解吸收、载药和缓释性能以及成骨活性等,而单一磷酸钙类人工骨载体材料在这些方面都有着各自不同的缺陷,而把多种材料进行组合优化,是研究的热点。

OBJECTIVE： To investigate the general attribute, release kinetics, and the good application value of calcium phosphate artificial bone as drug delivery system in the treatment of chronic osteomyelitis. DATA SOURCES： The related articles published in English bdtween January 1963 and December 2005 were searched in Medline database by using computer with the keywords of “calcium phosphate, artificial bone, drug delivery system, osteomyelitis”. Meanwhile, the Chinese relevant articles were searched in China National Knowledge Infrastructure （CNKI） and China journal full-text database with the keywords of “calcium phosphate, artificial bone, drug delivery system, osteomyelitis”. STUDY SELECTION： The articles were checked firstly, and the experimental studies were selected, and low-level repetitive studies and reviews were excluded, and then the full-texts of the rest articles were read through. DATA EXTRACTION： Totally 98 articles were collected, 23 were accordant with the inclusive criteria, and the other 75 were excluded due to their repetition. DATA SYNTHESIS： The collected data were categorized into 3 parts to discuss the general attributes of hydroxyapatite, triealeium phosphate and calcium phosphate bone cement, their application foreground in the treatment of the osteomylitis, the advantages and shortcomings of the carrier, and the release kinetic characteristics. CONCLUSION： The idea material about calcium phosphate artificial bone carrier should have the following characteristics： enough mechanical strength to bear the load; biecompatible and biodegradable; assist in the bone formation by osteoblasts. And that single calcium phosphate artificial bone carrier material all have their own defects in these aspects. So it is the researching focus to optimize many kinds of materials in recent years.