成纤维细胞生长因子生物蛋白海绵对创伤性溃疡修复的作用(英文)

Promoting effect of fibroblast growth factor biological protein sponge on repair of traumatic ulcer

背景:成纤维细胞生长因子生物蛋白海绵对创伤性溃疡修复的作用已经受到关注。目的:观察成纤维细胞生长因子生物蛋白海绵对创伤性溃疡的修复作用及可能发生的不良反应。设计:分组对比观察。单位:暨南大学医学院生理教研室。对象:选择2004-03/05暨南大学第一附属医院收治的皮肤创伤性溃疡患者40例,排除糖尿病及全身感染者,创伤性溃疡均位于小腿。随机分为试验组20例,对照组20例。干预措施:试验组20例用无菌成纤维细胞生长因子生物蛋白海绵,对照组20例用无菌凡士林油纱布。更换敷料1次/d,至创面愈合止。全身和局部均不使用影响创面生长的药品。于换药1,2,3周对创面愈合情况进行评估(创面分泌物分为:无、少量、中量及多量;创面边缘反应分为:无、轻度、中度及重度)记录创面愈合后的色素沉着及瘢痕情况。主要观察指标:两组患者溃疡愈合时间、创面愈合过程及不良反应。结果:两组共40例患者均进入结果分析。①两组患者治疗后创面愈合情况:试验组3周内愈合率显著高于对照组[95%(19/20),55%(11/20),χ2=8.533,P<0.05]试验组创面分泌物及创周炎性反应明显轻于对照组创面V两组创面均未发现明显不良反应及瘢痕。结论:成纤维细胞生长因子生物蛋白海绵可促进创伤性溃疡面愈合,缩短愈合时间,且无瘢痕及明显不良反应,是一种安全、方便、无刺激的理想敷料。

BACKGROUND： People have concerned with the effect of fibroblast growth factor biological protein sponge on the repairing effect of traumatic ulcer. OBJECTIVE： To observe the repairing effect of fibroblast growth factor biological protein sponge on the repairing effect of traumatic ulcer and its possible adverse reaction. DESIGN： Grouping comparison observation. SETTING： Staff Room of Physiology, Medical College of Jinan University. PARTICIPANTS： Totally 40 cases of traumatic ulcer accepted the treatment in the Fimt Hospital of Jinan Univerity between March 2004 and May 2005 were recruited. Patients with diabetes mellitus and infection on the whole body were excluded. Traumatic ulcer lay in the shank. Patients were randomly divided into experimental group and control group with 20 in each group. INTERVENTIONS： In the experimental group （n=20）, sterilized fibroblast growth factor biological protein sponge was used and in the control group （n=20）, sterilized petrolatum gauze dressing was used on the wound. Change the gauze dressing once per day until the wound healed. Drugs, which affected wound growth, were not used on the whole body and at the local part. Wound healing status was evaluated 1, 2 and 3 weeks after changing the drugs （The secretion of a wound was divided into： nothing, a little, middling, a great deal. frontier reaction of wound was divided into： nothing, slight, middling, severe.）. Pigment deposition and scar was recorded after wound healing. MAIN OUTCOME MEASURES： Healing time of ulcer, healing course of the wound and adverse reaction of the patients in the two groups. RESULTS： Totally 40 patients of the two groups entered result analysis. Wound healing status after treatment of the patients in the two groups： The rate of wound healing in 3 weeks in the experimental group was significantly higher than that in the control group [95% （19/20）,55% （11/20）, x^2=8.533,P 〈 0.05]. Wound secretion and peripheral inflammatory reaction of the wound in the experimental group was obwously mdder than that of the control group; there was no obvious adverse reaction and scar of the wound found in the two groups. CONCLUSION ： FGF biological protein sponge can promote the healing of traumatic ulcer;, shorten the healing time without scar and adverse reaction. This dressing is convenient, safe, and non-irritative.