幽门螺杆菌感染患儿血清IL-6、IL-8水平的变化

Changes of Serum IL-6,IL-8 Levels in Children with H.pylori Infection

目的:检测幽门螺杆菌(H.pylori)感染患儿血清IL-6、IL-8的水平变化.方法:采用ELISA法(酶联免疫吸附实验),测定32例H.pylori感染患儿和34例无H.pylori感染患儿血清IL-6和IL-8水平的变化.结果:IL-8在H.pylori感染组和无H.pylori感染组的浓度分别是(292.40±252.14)和(155.55±144.40)pg/mL,两组比较有差异性(P<0.05).IL-6在H.pylori感染组和无H.pylori感染组的浓度分别是(10.62±3.54)和(10.59±3.89)pg/mL,两组比较无差异性(P>0.05).结论:H.pylori感染患儿的血清IL-8水平会升高,而血清IL-6的水平不升高,IL-8可能参与了H.pylori感染的致病过程.

Objective. To explore the serum IL-6, IL-8 levels in children with H. pylori infection. Meth- ods： The semrn levels of IL-6, IL-8 were determined by ELISA anaong 32 children with H. pylori infection and 34 children without H. pylori infection. Results： The results show that the serum IL- 8 level distributions among 32 children with H. pylori infection and 34 children without H. pylori infection were （292.40±252.14） and （155.55 ± 144.40）pg/mL respectivdy （P 〈 0.05 ） whereas the serum IL - 6 level distribution armng the two groups were （10.62±3.54） and （10.58±3.89） pg/mL respectivdy （P 〉0.05）. Conclusion ： The serum level of IL-8 in children with H. pylori infection was increasing significantly while IL - 6 levels were not. It was shown that IL - 8 might take part in pathogenesis of H. pylori infection.