强的松对原发性肾病综合征患儿尿TGF-β1的影响

Urinary Transforming Growth Factor-β1 Levels in Children with Nephrotic Syndrome

目的:探讨肾病综合征(nephrotic syndrome,NS)患儿尿转化生长因子β1(transforming growthfactor-β1,TGF-β1)变化.方法:用ELISA法检测31例小儿NS尿TGF-β1水平,观察强的松治疗对患儿TGF-β1的影响并进行临床分析.结果:PNS患儿尿TGF-β1与正常对照组有显著差异(P<0.01),患儿尿TGF-β1与尿蛋白呈显著正相关(P<0.01),强的松治疗3个月,尿蛋白转阴的患儿尿TGF-β1显著下降(P<0.01),而未转阴组的患儿治疗前后无显著差异.结论:NS患儿尿TGF-β1显著升高,说明TGF-β1参与了患儿的免疫病理过程,强的松降低患儿尿TGF-β1可能是通过使蛋白尿消失来实现的.

Objective. To measure urinary transforming growth factor-beta 1 （TGF-β1） levels in children with nephrotic syndrome. Methods： ELISA was used to measure levels of urinary TGF-β1 in 28 children with nephrotic syndrome and 15 controls, and to analyse the treatment of children with nephrotic syndrome with prednimne. Results Results： Urinary TGF-β1 in children with nephrotic syndrome was significantly higher than that of the controls, and urinary TGF-β1 was significantly correlated positively with proteinuria; and the urinary TGF-β1 in prednisone- sensitive children with nephrotie syndrome was significantly decreased after treatment, and no significant difference in prednisone- resistant and predisone- dependent children was found. Conclusion： Urinary TGF-β1 is increased in children with nephrotic syndrome. It suggests that TGF-β1 may be involved in the immunopathological process of nephrotic children. Prednisone can reduce the levels of TGF-β1 in children with nephrotic syndrome.