床旁肌钙蛋白Ⅰ定量检测在急性冠脉综合征中的应用

The Study of Quantitative Bedside-testing of Troponin I in Acute Coronary Syndrome

目的:探讨心肌肌钙蛋白I(cTnI)快速床旁定量测定对急性冠脉综合征(ACS)诊断、鉴别诊断及预后判断的临床应用价值.方法:对60例ACS患者,其中23例急性心肌梗死(AMI)、37例不稳定型心绞痛(UAP),24例非心源性胸痛患者同时做cTnI定量及CK-MB测定,进行各组间比较分析.结果:AMI组cTnI、CK-MB明显高于UAP组及对照组,有显著差异(P<0.0001).UAP组cTnI明显高于对照组(P<0.001),CK-MB无显著差异(P>0.05);UAPⅢ级的cTnI阳性率明显高于Ⅰ、Ⅱ级(P<0.001).结论:cT-nI床旁快速定量测定方便、省时,对ACS患者的诊断、鉴别诊断及预后预测具有重要的意义和临床实用价值.

Objective. To evaluate the diagnosis, differentiate diagnosis and prognosis of the quantitative bedside-testing of troponin Ⅰ （cTnI） in acute coronary syndrome （ACS）. Methods. Serum cTnI and CK- MB levels were measured in 60 ACS patients, 23 of them were AMI, 37of them were UAP, 24 of them were none- cadiac chest - pain （control group）. Results. Serum cTnI and CK - MB levels in the AMI group were higher than those of UAP group and the control group （P （0.0001）. cTnI levels in UAP group were higher than those of the control group （P 〈0.001）. CK - MB levels haven＇t striking differences （P 〉0.05）, The cTnI positive rate in UAPⅢ were higher than those of UAP Ⅰ and UAPⅡ （P〈0.001）. Concltusion. It is shown that the quatitative bedside - testing of cTnI is a convenient, time - saving method in the differentiate diagnosis and prognosis in ACS.