他汀类药物对炎性关节炎的潜在治疗作用

Potential use of statins in the prevention of inflammatory arthritis

他汀类药物,即3-羟基-3-甲基戊二酰辅酶A(HMA-CoA)还原酶抑制剂,可减少动脉粥样硬化的形成和心血管事件的发病率及死亡率。上述作用源自该类药物对胆固醇代谢的影响以及下调低密度脂蛋白的合成。目前越来越多的证据显示,除上述作用外,他汀类药物还有更广泛的作用,包括对炎症途径的影响、免疫调节活性、控制类风湿关节炎病情的活动、降低血管危险性和对炎性关节炎的潜在治疗作用。

HMG-CoA reductase inhibitors （statins） reduce risk of atherogenesis as well as cardiovascular morbidity and mortality by the modulation of cholesterol metabolism and inhibition of the LDL synthesis. More and more evidences support statins＇ potential anti-inflammation, immunomodulation,suppression of RA disease activity and vascular risk. Statins shows potential benefits in the prevention of articular inflammation.