甲硝唑、硫糖铝、乳酸菌素治疗溃疡性结肠炎的临床研究

Clinical study of ulcerative colitis' therapy with metronidazole, sucralfate and lactobacillus

目的探讨甲硝唑、硫糖铝、乳酸菌素治疗UC疗效。方法本组52例,其中男35例,女17例,年龄20￣59岁,平均31.0岁,随机分为灌肠组(32例)和口服组(20例),灌肠组用甲硝唑0.6g+硫糖铝3.0g+乳酸菌素2.4g保留灌肠;口服组:柳氮磺胺吡啶,4￣6g口服,3/d,疗程均为2、3周。结果症状改善灌肠组总有效率为93.8%,而口服组为85.0%(χ2=0.3112,P>0.05)。起效时间灌肠组14d,总有效率为81.3%,口服组治疗14d,其总有效率仅50.0%,前者略高于后者,差异有显著性(P<0.05)。内镜及病理组织示炎症改善基本一致,灌肠组总有效率为87.5%,而口服组为75.0%,前者略高于后者,但差异无显著性(χ2=0.6122,P>0.05)。副反应:灌肠组近期反应稍多,但多能忍受,但停药1周内恢复;口服组毒副反应稍多,但有的毒副反应难以忍受。结论UC应用甲硝唑、硫糖铝、乳酸菌素保留灌肠,疗效确切,起效时间比SASP稍早,毒副反应稍多,但病人依从性好。

[Objective] To investigate the therapy effect of UC with metronidazole, sucralfate and lactobacillus. [Methods] 52 cases, male： 35 cases, female： 17 cases; age ranged from 20-59 years, averaged 31.0 years. Random allocation to enema group （32） and oral administration group（20）. Enema group： retention-enama with emtronidazole 0.6 g＋sucarlfate 3.0 g＋lactobacillus 2.4 g. oral administration group： oral administrate with fulfasalazine. The course of treatment was 2, 3 weeks. [Results] Enema group and oral administration group. The total effective rate were 93.8% and 85.0%. X^2-=0.3112, P 〉0.05. Most of enema group＇s first effect time was 14 days, but oral administration group＇s was 14 days. Endoscope and pathology： the inflammation＇s change was almost the same, total effective rate were 87.5% and 75.0%. X^2=0.6122, P 〉0.05. Side effect： enema group＇s side effect was more than oral administrtion group, it was easy to tolerate, stop the treatment, side effect will disappear after one week. [Conclusion] The therapy effect of retention-enemema with metronidazole, sueralfate and lactobacillus is certain.