妇女生殖道支原体感染现状及药敏分析

Iinfective characteristic and analyzing susceptibility to antibiotics of mycoplasma in women genitourinary

目的了解妇女生殖道支原体感染现状及支原体对10种常用的抗生素敏感性。方法对有生殖道感染症状或/和体征的3128例妇女按年龄不同分为4组,组Ⅰ(17￣30岁)、组Ⅱ(31￣40岁)、组Ⅲ(41￣50岁)、组Ⅳ(>50岁)。取宫颈分泌物进行支原体培养+药敏试验。结果3128例患者宫颈分泌物支原体阳性者共1992例,感染率63.88%,其中解脲支原体阳性1958例,感染率62.60%,人型支原体阳性436例,感染率13.92%。1992例中有402例同时感染解脲支原体和人型支原体。4组解脲支原体感染率分别为62.36%、63.25%、66.67%、40.00%,组Ⅰ￣Ⅲ3组间感染率差异无显著性,而组Ⅳ感染率明显低于前三个组(P<0.05)。选取资料保存完整的732株解脲支原体药敏结果分析,显示解脲支原体对交沙霉素最敏感(敏感率97.27%),最低的是壮观霉素(敏感率8.20%)。结论生育年龄妇女生殖道支原体感染率较高,以解脲支原体为主,支原体对抗生素的药敏性已发生变化,过去常用的红霉素耐药株明显增加,交沙霉素敏感性最高。

[Objective] To determine the mycoplasma infection and the drug sensitivity to 10 common-used antibiotics in women genitourinary. [Methods] According to different age, 3128 women with symptom of genitourinary infection were divided into 4 groups, and which were respectively group Ⅰ （17-30 years old）, group Ⅱ （31-40 Y）,group Ⅲ （41-50 Y） and group Ⅳ （〉50 Y）. Mycoplasma culture and susceptibility of antimicrobial agents was carried out with the discharge of cervix. [Results] 1992 of 3128 cases were infected with mycoplasma. The total positive rate was 63.88%. The positive rate of Ureaplasma urealyficum（Uu） or Mycoplasma Hominis （Mh） infection were respectively 62.60%（1958 cases） and 13.92%（436 cases）. 402 of 1992 cases were infected with both UU and MH. The Uu infection rates among 4 groups were 62.36%, 63.25%, 66.67% and 40.00% respectively. From group I to group III, the infection rates were no obvious difference among them, but the rate of group IV was significant low- er than those of the first three groups （P 〈0.05）. By analyzing the drug sensitivity assay of 732 Uu, it was concluded that the most highly sensitive drug to Uu be Josamycin（sensitivity rate 97.27%） and the most lowly sensitive drug be Spectinomycin（8.2%）. [Conclusion] Mycoplasma infection rate in genitourinary is higher in childbearing age women and the dominating infection is UU. The susceptibility of mycoplasma to antibiotics has been changed. Common-usde Erythromycin has been obviously resistant and Josamycin been the most highly sensitivity.