口腔扁平苔藓患者白色念珠菌分离株的颊细胞粘附力研究

Adhesion to Buccal Epithelial Cells of Candida albicans Isolates from Oral Lichen Planus

目的研究健康人和口腔扁平苔藓患者口腔白色念珠菌分离株的颊细胞粘附力。方法应用颊细胞粘附实验法,比较来自于健康人(26株)、糜烂型口腔扁平苔藓患者(62株)以及非糜烂型口腔扁平苔藓患者(24株)共112株白色念珠菌对人颊细胞粘附力的大小。结果糜烂型口腔扁平苔藓患者组的白色念珠菌分离株的平均粘附数较健康对照组高(P<0.05),说明糜烂型口腔扁平苔藓患者组白色念珠菌分离株的颊细胞粘附力高于健康对照组。结论糜烂型口腔扁平苔藓患者组的白色念珠菌分离株与健康对照组相比,具有不同的毒性特征,白色念珠菌与糜烂型口腔扁平苔藓发生发展可能相关。

Objective To investigate the adhesion to buccal epithelial cells of Candida albicans isolates from erosive oral lichen planus（OLP） and nonerosive OLP, and its role in the development of OLP. Methods A total of 112 isolates, comprising healthy control （26） ,erosive OLP （62） and nonerosive OLP （24）, were screened for the adhesion by using buccal epithelial coil （BEC） assay. Results The adhesion to buccal epithelial cells of the isolates from erosive OLP group was stronger than that of those from healthy control. Conclusion Candida albicans, some isolates with a special virulence attribute may contribute to the occurrence and progression of erosive OLP.