高危人乳头瘤病毒基因型与宫颈癌筛查

Clinical Studies of the High-Risk Human Papillomavirs Genotypes for Cervical Cancer Screening

应用第二代基因杂交捕获技术(HC-Ⅱ)对7068例21～58岁妇女宫颈细胞进行13种高危型人乳头瘤病毒(HPV)DNA的检测。该人群中13种高危型HPVDNA的总检出率为23.45%。在检出的1440例HPV阳性者中,宫颈癌、宫颈上皮内高度病变(CINⅡ/Ⅲ)及宫颈上皮内低度病变(CINⅠ)的高危型HPVDNA检出率分别为100%、100%、65.06%。女性生殖道高危型HPV感染是宫颈癌及CIN流行的主要危险因素,提示宫颈癌的防治应重点预防HPV感染,而对HPV感染的筛查和密切监测应是已感染高危型HPV的对象。

To unveil the statistical picture of human papillomavirs （HPV） infection in the female population of Shenzhen Special Economical Zone, and to study the relationship between cervical cancer and infection with the 13 high-risk HPV genotypes. HPV DNA tests were conducted among 7 068 women （aged 21-58） using Digene＇s HC-Ⅱ gene hybrid signal amplification technique. The 13 high-risk HPV genotypes were detected in 1 440 （23.45%） of the studied female population, including 25 （100%） cervical cancer, 23 （1005%） CINⅢ, 62 （100%） CINⅡ and 108（65.06%） CIN IⅠ. The high-rlsk HPV infection is the main danger factor in developing cervical cancer and CIN, thus prevention of the cancer should be focused on the prevention of HPV infection. Furthermore the population group infected with the high-risk HPV genotypes should be the targets for the screening and monitoring of HPV infection.