脆性组氨酸三联体基因研究进展

Advances on the Gene of Fragile Histidine Triad

脆性组氨酸三联体(FHIT)基因定位于染色体的3p14.2,经细胞生物学、肿瘤分子生物学研究,及转基因、基因敲除技术等实验证实其为抑癌基因。FHIT主要通过某种信号途径诱导凋亡,从而抑制肿瘤细胞的增殖。研究认为,FHIT通过FHIT-底物复合物产生抑癌作用。越来越多的研究结果表明FHIT在肿瘤的预防和治疗中具有很好的应用前景。

The fragile histidine triad （FHIT） gene is located at chromosome 3p14.2, and it is identified as a tumor suppressor gene by using cell biology, tumor molecular biology, transgene and gene knockout mice. FHIT gene is involved in the induction of apoptosis and the inhibition of proliferation in tumor cells by some signal pathway, and it is found that FHIT can suppress tumorigenicity by Fhit-Ap3A signaling complex. The strong evidence shows that FHIT-based gene therapy may be an effective strategy in cancer prevention and treatment.