核苷类药物酶法合成研究进展

Enzymatic Synthesis of Antiviral Nucleotide

由于核苷类似物具有很高的抗病毒活性,因为而已成为医药工作者研究的重点。运用酶法合成核苷类似物,已经显示了巨大的优势。本文综述了酶法合成核苷类似物的产生菌种和酶系,以及它们的催化机理,并罗列了已经用于生产或较有使用价值的菌种。

Nucleoside analogues have potent antiviral activity and have been noticed as a very important research area. This paper reviewed the applications of enzymes in synthesis of nucleoside analogues and enzyme catalytic mechanism.