CD4^+CD25^+和CD8^+调节性T细胞的作用机制

Mechanism of CD4^+CD25^+ and CD8^+ Regulatory T cells —— Review

调节性T细胞(Treg)主要在机体免疫系统中发挥负向调节作用,既能抑制不恰当的免疫反应,又能限定免疫应答的范围、程度及作用时间,对CD4+和CD8+效应性T淋巴细胞的增殖起抑制作用,因此在移植物抗宿主病、自身免疫病、过敏性疾病等的发病机制和临床治疗中有潜在的应用价值。本文重点介绍CD4+CD25+Treg和CD8+Treg的作用机制,并简述调节性T细胞研究面临的挑战与展望。

Regulatory T cells （Treg） play a key role in the negative regulation of the immune system, which can inhibit inappropriate self-reactive T cells, as well as limit the range, extent and lasting time of immune responses, so as to inhibit the proliferation of CD4^＋ and CD8^＋ effector T cells. In view of these properties, there is little doubt about the enormous potential value of Tregs in molecular mechanisms and clinical treatment of human autoimmune disorders, graft- versus-host disease （GVHD） and allergies. In this review, the molecular mechanisms of CD4^＋CD25^＋ Treg and CD8^＋ Treg were mainly discussed, and challenge with which study on Treg cells is faced and prospects were briefly described.