恶性血液病血管新生过程中VEGF/R、内皮抑素和基质金属蛋白酶的相互调控探讨

Interregulation of VEGF/R Endostatin and MMP in the Angiogenesis of Hematologic Malignancies —— Review

恶性血液病血管新生过程中涉及的一些因子,如血管内皮生长因子/受体系统(VEGF/R)、基质金属蛋白酶(MMP)和内皮抑素等(ES)所起的作用及其相互调控机制一直是学术研究的热点。虽然近年来相关研究发展很快,但仍未能形成系统理论。本文就近年来有关VEGF/R系统的正负调控因素,MMP的调控及其与VBGF/R的相互影响,ES的调控及其与VEGF/R和MMP的相互影响等研究进展作一综述。

Some kinds of angiogenic correlation factors, e.g. VEGF/R, MMP, endostatin, are relative to the process of hematologic malignancies. The mechanisms of adjusting themselves and controlling mutually have been hot points of the academic research in last few years. Alhough the rapid progress has been made in studies of this feild, it is still hard to come into a systematic theory now. This article introduces the last progress in the field of positive and negative regulatory factors of VEGF/R system in the angiogenesis of hematologic malignancies, the regulation of MMP and its relation with VEGF/R, the regulation of ES and its relation with VEGF/R and MMP.