摘要
目的:观察经皮神经电刺激(TENS)法刺激大鼠涌泉穴的fMRI表现,为揭示针灸镇痛的中枢机制提供可视实验数据。方法:使用热板仪测定大鼠TENS前后痛阈的变化,利用fMRI血氧水平依赖(BOLD)技术获取TENS涌泉穴的脑功能图像,并显示激活区域。结果:实验组TENS 20 min后痛阈值比实验前显著提高,与对照组相比差异有显著性意义;经皮神经电刺激大鼠右足涌泉穴时大脑激活区域有双侧的额叶皮质1区、2区、双侧的扣带皮质1区、2区、对侧的尾壳核、对侧岛叶皮质、皮质后肢代表区和顶皮质1区。结论:TENS后大鼠痛阈显著增高,提示针刺涌泉穴具有镇痛效应;其机制可能与引起中枢内与痛有关的皮层激活,从而使针刺部位的传入冲动在中枢神经系统内整合,并通过调节神经递质和激素的释放而对疼痛产生抑制作用。
Objective：To elucidate central mechanism of acupuncture analgesia by observing the presentation of fMRI induced by TENS of acupoint “Yongquan” in rats. Methods：To determine the pain thresholds of rats by using hot plate analgesia meter and to access the activated areas by using the brain BOLD fMRI. Results：The pain thresholds of experiment group increased significantly and were much higher than those of control group. The activated areas included bilateral frontal lobe cortex,primarily section 1,2; cingulated gyrus, primarily section 1,2 ; contralateral caudate nucleus, insula, backlimb representation cortex and parietal lobe cortex, primarily section 1. Conclusion：The significant increasing of the rats＇ pain thresholds by TENS suggests acupuncture may involve the integration of pain processing in muhiple brain regions and may produce inhibitory effects of pain through modulating the release of neurotransmitter and hormone.
出处
《放射学实践》
2005年第12期1087-1089,共3页
Radiologic Practice
基金
国家自然科学基金资助项目(90909008)
关键词
经皮神经电刺激
磁共振成像
痛阈
Transcutaneous electric nerve stimulation
Magnetic resonance imaging
Pain threshold
