肥厚型心肌病左室局部心肌收缩功能的应变率成像研究

Assessment of Left Ventricular Regional Myocardial Systolic Function by Strain Rate Imaging in Patients with Hypertrophic Cardiomyopathy

目的:应用应变率成像(SRI)评价肥厚型心肌病(HCM)患者左室纵向局部心肌收缩功能。方法:应变率成像模式下,分析18例HCM患者和17例健康对照组左室各室壁基底段、中段、近心尖段局部心肌纵向应变率曲线,测量收缩期峰值应变率。结果:HCM组各室壁节段收缩期峰值应变率均显著低于正常对照组相应室壁节段;室间隔中段收缩期峰值应变率与室间隔厚度以及室间隔-左室后壁厚度比值(IVS/PW)之间均具有显著相关性(rSR-IVS=0.776,rSR-IVS/PW=0.734,P<0.01)。结论:HCM患者左室局部心肌收缩功能受损,且左室形态学异常与局部心肌功能的异常具有相关性;应变率成像能够定性、定量地评价局部心肌收缩功能。

Objective： This study was performed to assess the left ventricular regional systohc functiononapical images by strain rate imaging in patients with hypertrophic cardiomyopathy （HCM）. Methods：In 18 patients with EICM and 17 normal subjects,regional longitudinal strain rate was assessed at the basal,mid,and apical segments of the different walls of left ventricle. The peak systolic strain rate of each segment was measured and all the results were compared between the two groups. Results： Patients with HCM had reduced peak systolic strain rate at every segment of different walls compared with normal subjects. There were significant correlations between the midseptal peak systolic strain rate and the thickness of IVS （rSR-IVS=0.776）,so was between the midseptal systolic strain rate and the ratio of IVS to LVPW thickness（rSR-IVS PW = 0.734 ）. Conclusion： The results demonstrate that the left ventricular longitudinal regional myocardial systolic function is abnormal in HCM,and the degrees of left ventricle hypertrophy and asymmetry are related to the myocardial regional systolic function in HCM. Therefore, strain rate imaging has the potential to assess regional myocardial systolic function qualitatively and quantitatively.