宫颈鳞癌组织中PD-ECGF C-erbB-2Cath-D的表达及临床意义

The Studies on Expression of PD-ECGF, C-erbB-2 and Cath-D inCervical Squamous Cell Carcinoma and Clinical Significance

目的:探讨PD-ECGF、C-erbB-2和Cath-D三种蛋白在宫颈鳞癌中表达的临床意义及其相关性。方法:应用免疫组化法检测87例宫颈鳞癌组织及23例对照组中PD-ECGF、C-erbB-2和Cath-D的表达,采用!2检验,分析三种蛋白表达与临床病理参数的关系。结果:1)PD-ECGF在宫颈鳞癌中表达率高且与临床分期及组织分化程度有关;2)C-erbB-2在宫颈鳞癌中的表达率和对照组比较,差异有显著性(P<0.01);表达率与临床分期、组织分化程度有显著相关性(P<0.05);3)Cath-D的阳性表达率高于对照组,其表达与宫颈鳞癌组织分化程度、淋巴结转移相关;4)C-erbB-2与Cath-D之间阳性表达有显著相关性(P<0.05)。结论:PD-ECGF、C-erbB-2及Cath-D可作为判断宫颈鳞癌生物学行为的重要指标。

Objective： To investigate the expression of PD-ECGF, C-erbB-2 and Cath-D in cervical squamous cell carcinoma and their clinical significance and relationship among them. Methods： By using immunohistochemistry to detect PD-ECGF, C-erbB-2 and Cath-D in 87 cases of cervical squamous cell carcinoma and 23 samples of dysplasia of cervical epithelium and normal cervical tissues. The relationship between their expression with clinicopathologic factors was analyzed by chisquare test. Results： 1） The expression rates of PD-ECGF are in connection with cellular differentiation and cervical squamous cell carcinoma of clinical stage. 2） The expression rate of C-erbB-2 elevated paralleling the escalation of the clinical stage and the cellular differentiation of cervical carcinoma （P〈 0.05）. 3） The expression rate of Cath-D was in connection with cellular differentiation and lymph nodes metastasis （P〈0.05）. 4） There was a relationship between expression of C-erb B-2 and Cath-D （P〈0.05）. Conclusion： The result suggests that the expression of PD-ECGF, C-erbB-2 and of Cath-D are closely related to growth, invasion and metastasis of the cervical squamous cell carcinoma.