摘要
目的:比较转化糖与葡萄糖静脉输注后对血糖水平的影响,评价其用于临床能量补充的有效性与安全性。方法:①选择2002-10/2002-12收治于解放军第三军医大学西南医院肝胆外科和呼吸科病房需静脉能量补充的住院患者44例。年龄18~65岁,且均已签署知情同意书。随机将患者分为2组:实验组(n=21)与对照组(n=23)。实验组:给予50g/L转化糖注射液静脉输注,500mL/次,1次/d,疗程为3d。对照组:给予50g/L葡萄糖注射液用法及疗程同转化糖。②于给药前、给药结束时、给药后2h测定血糖浓度,并同时于实验前和实验结束后检测肝、肾功能,观察用药不良事件。③计量和计数资料差异性比较分别采用t检验和χ2检验。结果:患者44例均进入结果分析。①给药前、给药后即刻、给药后2h两组血糖水平差异不明显(P>0.05)。两组治疗第1~3天给药后即刻均出现血糖明显一过性升高,高于给药前(t=5.74~7.84,P<0.01)。给药后2h实验组血糖水平均恢复到给药前水平,而对照组治疗第2天给药后2h明显高于给药前(t=2.62,P<0.05),表明对照组血糖水平恢复到给药前水平速度较实验组稍慢。②实验过程中两组患者均无不良反应发生,50g/L转化糖注射液对肝、肾功能、血尿酸等指标无影响。结论:输注50g/L转化糖注射液后血糖水平波动小于50g/L葡萄糖注射液,50g/L转化糖注射液用于临床患者机体能量补充安全有效。
AIM: To compare the effects of invert sugar and glucose injected into vein on glucose level, and evaluate its effectiveness and reliability in clinic for energy supply.
METHODS: (1) Forty-four hospitalization patients, who needed energy supply and treated at the wards of Department of Liver and Gall Surgery, Department of Respiration, Southwestern Hospital, Third Military Medical University of Chinese PLA from October to December 2002, were selected, aged from 18 to 65 years, and all signed the informed consents. They were randomly divided into 2 groups: experimental group (n=21) and control group (n=23). The patients in the experimental group were given 50 g/L invert sugar injected into vein, 500 mL per time, once a day, 3 days as a course. Those in the control group were treated with 50 g/L glucose parenteral solution. The usage and course were the same to that of invert sugar. (2) Glucose concentration was detected at pre-administration, the end of administration and 2 hours after administration. Liver function and renal function were tested before experiment and after experiment in the same time. The adverse event of medication was observed. (3) Differences of measurement data and enumeration data were compared with t-test and test.
RESULTS: Totally 44 patients were involved in the result analysis. (1) The glucose levels had insignificant difference in the two groups before administration, at the moment of administration and 2 hours after administration (P 〉 0.05 ). Glucose increased significantly immediately after administration for 1-3 days in the two groups, which was higher than that before administration (t=5.74-7.84,P 〈 0.01). Glucose level recovered to that before administration in the experimental group at 2 hours after administration, while it was higher at the 2^nd day in the control group after administration for 2 hours than that before administration (t=2.62,P 〈 0.05), which indicated that the recovery of glucose to that before administration in the control group was slow as compared with the experimental group. (2) There was no side reaction in the patients of the two groups in experiment. The 50 g/L invert sugar parenteral solution had no effects on liver function, renal function and serum uric acid, etc.
CONCLUSION: Compared with 50 g/L glucose parenteral solution, the changes of blood glucose levels in 50 g/L invert sugar is slighter. 50 g/L invert sugar injection is effective and safe for physical energy supply in hospitalization patients.
出处
《中国临床康复》
CSCD
北大核心
2005年第43期50-51,共2页
Chinese Journal of Clinical Rehabilitation