生物材料与血液相互作用过程的研究进展

Developments in Understanding of Interactions between Blood and Biomaterials at Molecular and Cellular Levels

血液相容性是制约生物材料在血液环境中应用的一个关键因素。材料的血液相容性主要取决于材料与血液之间一系列的相互作用过程。近年来,随着对蛋白质结构检测手段的增加,以及分子生物学技术的发展,对材料与血液的相互作用过程的研究也逐步深入到分子结构水平。国际上越来越多地应用分子生物学的方法,从多角度分析材料表面结构和组成对血液中蛋白质分子和细胞功能与结构的影响。本文主要归纳了近年来国际上在生物材料与血液相互作用研究方面出现的一些新的视点和方法,并对它们的特点以及发展趋势进行了探讨。

Blood compatibility is one of the most important factors for biomaterials applied in blood-contacting environment, which is determined by a series of complicated interactions of blomaterials surfaces with both soluble and cellular components in blood. As the development of molecular biology technology and emergence of new characterization methods for changes of protein conformation structure and function, more and more researchers are making intensive efforts to understand hemocompatibility of biomaterials at molecular and cellular levels. In this paper, developments in understanding of interactions between blood and materials surfaces, especially the changes of plasma protein conformation structure and activation of platelets induced by biomaterials surfaces, are reviewed.