破骨细胞骨吸收的分子机制

Molecular Mechanism of Bone Absorption in Osteoclast

破骨细胞性骨吸收是在骨的微环境内进行的复杂分子生物学反应过程,涉及到众多蛋白质和调控因子的参与。有关破骨细胞的活化,骨基质的吸收,骨吸收的调控等方面,现有的数据还不够充分。本文综述了金属基质蛋白酶(M atrix m eta lloprote inases,MM P s)在破骨细胞移行和骨基质吸收方面的重要作用,以及破骨细胞分化因子(R eceptor activator of NF-κB-ligand,RANKL)和护骨素(O steoprotegerin,OPG)在骨吸收调控网络中的地位。

The physiological reconstruction of bone is strictly dependent on bone resorption. Bone resorption is believed to be a complicated molecular reaction process that occurs in the microcircumstance of bone tissue. A lot of enzymes and factors take part in this process, yet there are not enough data with reference to the activation of osteoclast, resorption of bone matrix, regulation of bone resorption. In this paper we review the importance of matrix metalloproteinases （MMPs） in transfer of osteoclast and degradation of bone matrix, and the function of receptor activator of NF-κB-ligand （RANKL） and osteoprotegerin （OPG） in regulation of bone resorption.