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视网膜母细胞瘤组织中PTEN蛋白表达的意义 被引量：2

Significance of PTEN protein expression of in retinoblastoma
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摘要 目的:探讨PTEN蛋白在视网膜母细胞瘤(RB)组织中的表达及临床意义.方法:采用免疫组化SP法观察36例RB和10例正常视网膜组织石蜡标本中PTEN的表达情况.结果:21例(58.3%)RB组织中PTEN蛋白表达阳性,与正常视网膜组织相比(0%)存在显著性差异(P=0.0000).PTEN蛋白在分化和未分化RB组织中的表达率分别是73.7%和41.2%(P<0.05);在Ⅰ,Ⅱ,Ⅲ期RB组织中的表达率分别是75.0%,62.5%和41.7%(P<0.05).随肿瘤细胞病理分型、临床分期的增高,PTEN蛋白阳性表达率明显降低.结论:PTEN蛋白异常表达在RB的进展中有重要作用,检测PTEN的表达有助于判断病情与预后. AIM： To investigate the expression of PTEN protein in retinoblastoma and its clinical significance. METHODS： Expression of PTEN protein was detected in 36 specimens of retinoblastoma and 10 specimens of normal retina using SP immunohistochemistry. RESULTS： The positive rate of PTEN protein（21 cases, 58.3% ） in retinoblastoma was much more frequent than that of normal retina （0%, P =0.0000） and the expression level of PTEN varied between the pathology grades （differentiated 73.7% ; undifferentiated 41.2%, P〈0.05） and among the clinic stages （stage Ⅰ 75.0%; stage Ⅱ 62.5%; stage Ⅲ 41.7%, P〈 0.05）. The higher the pathology grade and the clinical stage of tumors, the lower the expression of PTEN protein. CONCLUSION： The abnormal expression of PTEN protein may play an important role in the development of retinoblastoma. Detection of PTEN protein may be useful for the assessment of retinoblastoma development and its prognosis.
作者 连黎红 杨万广
机构地区 河南大学第一医院眼科
出处 《第四军医大学学报》 北大核心 2005年第23期2183-2184,共2页 Journal of the Fourth Military Medical University
关键词 视网膜母细胞瘤 PTEN蛋白 免疫组化 肿瘤细胞 retinoblastoma PTEN protein immunohistochemistry
分类号 R739.7 [医药卫生—肿瘤]
  • 相关文献

参考文献6

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二级参考文献12

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共引文献10

同被引文献35

  • 1孙宪丽.视网膜母细胞瘤近代治疗[J].眼科,2004,13(6):325-330. 被引量：15
  • 2王翠芝,周小鸽,黄受方,王鹏.组织芯片的有效性研究[J].临床和实验医学杂志,2005,4(4):193-195. 被引量：2
  • 3龙华,姜发纲.MMP-2和MMP-9在视网膜母细胞瘤中的表达及意义[J].眼科新进展,2006,26(12):908-910. 被引量：11
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引证文献2

二级引证文献10

第四军医大学学报
2005年 第23期

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