Askin瘤临床病理——附4例报告

Clinicopathological research of Askin tumor: report of 4 cases

目的探讨Askin瘤临床及病理特征。方法回顾性分析北京大学深圳医院和广州军区总医院收治的4例Askin瘤的临床病理资料。结果4例中,男女各2例,年龄21～52岁。以胸痛为主要症状,均发生于胸壁,2例侵润肺,2例侵润膈肌。光镜下见瘤细胞为小圆形,细胞大小较一致,排列成巢状、小叶状。2例电子显微镜检查均见神经内分泌颗粒和神经丝。免疫组织化学染色中神经元特异性烯醇化酶(NSE)、CD99、S-100蛋白阳性数分别4/4、3/4、2/4。2例经细胞遗传学检查均见特异性染色体异位[t(11;22)(q24;12)]。2年存活数2例。结论Askin瘤是一种发生于胸部的高度恶性的神经内分泌肿瘤。

Objecie To investigate the clinicopathological features of Askin tumor. Methods The clinical and pathological data of four patients with Askin tumors in Peking university Shenzhen hospital and Guangzhou general hospital were studied retrospectively. Results Four cases of Askin tumors included 2 men and 2 women, whose ages ranged from 21 to 52. All four patients complained with chest pain. The lungs were infiltrated in two cases, and the phrenic muscles were invaded in two cases. The nest-like or lobular structures composed of small round cells were found under the microscope. Neurocrine granule and neurofilaments were seen under electron microscope in two cases, hnmunhistochemical reactivity for NSE, CD99, and S-100 protein were positive 4/4, 3/4, 2/4. Chromosome dislocations [t（11;22）（q24;12）] in 2 cases were found under the cytogenetics methods. Only two cases had survived for two years Conclusion Askin tumor is a highly malignant neuroendocrine tumor in thoracic region.