定量脑电图对奥拉西坦治疗轻中型脑损伤疗效评价

Evaluation with quantitative EEG on effect of oxiracetam on mild and moderate brain injury

目的利用定量脑电图监测来评价益智药奥拉西坦治疗轻中型脑损伤的疗效。方法采用随机双盲对照试验,对照药物为吡拉西坦。将连续收治的48例轻中型脑损伤患者随机分入奥拉西坦组和吡拉西坦组,每组24例。分别于用药前、用药21d后进行定量脑电图数据采样。统计分析各组用药前后定量脑电图差异;比较两种药物对定量脑电图的影响。结果两组患者用药后的定量脑电图均有明显改善(P<0.05);奥拉西坦对脑电图的影响较吡拉西坦更大(P<0.05)。结论奥拉西坦对轻中型脑损伤患者脑功能的改善有明显促进作用,且功效较吡拉西坦更强。

Objective To assess the effect of nootropics oxiracetam on mild and moderate brain injury by quantitative electroencephalogram （qEEG）. Methods A study of randomized double-blind contrast test was performed with piracetam as contrast medicine. A total of 48 consecutive patients with either mild or moderate brain injury was randomly assigned to either oxiracetam group or piracetam group with 24 cases in each group. The recordings of qEEG were obtained before administration of the agents and ：21 days after the treatment respectively. The difference in qEEG before and after medication was analyzed statistically and the effects of two medicines on qEEG were compared. Results The significant improvement in qEEG was found in both groups after treatment （ P 〈 0. 05 ）. The effect of oxiracetam on qEEG was more significant than that of paracetam （P 〈0.05）. Conclusion Oxiracetam can distinctly improve the brain function of the mild and moderate brain injury and it has better efficacy than piracetan.