摘要
目的观察颈动脉粥样硬化(AS)斑块内纤溶酶原激活抑制物-1(PAI-1)的mRNA和抗原的表达情况。方法分别应用原位杂交和免疫组织化学测定颈AS斑块内PAI-1mRNA和抗原表达。结果相对于正常动脉内膜,颈AS病变内膜PAI-1阳性细胞数明显增多(P<0.05),其中颈AS严重病变肩区阳性细胞数最多,且以单核-巨噬细胞为主。结论PAI-1与颈AS发生有关。
Objective To observe the mRNA and antigen expression of PAI-1 in the carotid atherosclerotic plaques. Methods Antigen and mRNA of PAI-1 was measured by immunocytochemistry and hybridization in situ respectively. Results PAI-1-positive cells in the intimas of the Carotid AS plaques increased more than those in the intimas of the normal arterial walls. There were many PAI-1-positive cells in the shoulder areas of the advanced lesions. The positive cells in the shoulder areas were mainly monocytes and macrophages. Conclusions ICAM-1 is associated with the carotid atherosclerosis.
出处
《卒中与神经疾病》
2005年第6期329-333,共5页
Stroke and Nervous Diseases
