前列腺特异性抗原前体用于前列腺癌早期诊断

Recent Advances in proPSA on Early Detection in Prostate Cancer

PSA前体(proPSA)是血清游离PSA的特殊形式,由天然proPSA及其各种剪接的亚型组成,其中[-2]proPSA和[-4]proPSA和前列腺癌(PCa)的相关性高于[-7]proPSA和[-5]proPSA。临床研究表明,[-2]proPSA可以显著提高PCa的检测能力,特别是血清PSA低于4μg/L时。本文对proPSA的形成机制、特点及其对PCa早期诊断的影响进行了综述。

The precursor of prostate specific antigen （proPSA） are distinct molecular forms of free PSA in serum, proPSA is comprised of native proPSA as well as several truncated forms, in which [-2 ] proPSA and [-4] proPSA are more prostate cancer （PCa）-associated than [ -7 ] proPSA and [ -5 ] proPSA. Clinical studies have recently provided evidence that [ -2 ] proPSA can significantly improve the detection of PCa, particularly in patienls with total serum PSA values less than 4μg/L. In this paper, the mechanism and characteristics of proPSA formation and impact of proPSA on the early detection of PCa are reviewed. Natl J Androl,2005,11 （ 12 ） ：944-946