不同剂量贫铀污染对大鼠皮层及海马结构生长抑素阳性神经元的影响

Influences of different doses of depleted uranium particles on somatostatin positive neurons in cortex and hippocampus in rats

目的:探讨贫铀污染对大鼠皮层及海马结构SS阳性神经元的影响。方法:采用不同剂量贫铀颗粒气管灌注大鼠3个月后,观察大鼠皮层及海马结构各区SS阳性神经元形态和数目的变化情况。结果:DU 1 mg组、DU 3 mg组和DU 5 mg组大鼠皮层SS阳性神经元染色较浅,阳性神经元数目与NS组比较均明显减少。海马结构各区DU 3 mg组和DU 5 mg组SS阳性神经元染色较浅,阳性神经元数目与NS组比较也明显减少。结论:贫铀污染能引起大鼠皮层和海马结构SS阳性神经元数目减少, 并可能通过此途径引起脑功能障碍。

Objective： To explore the changes of somatostatin positive neurons in cortex and hippocampus in rats instilled with depleted uranium particles. Methods： Rats were exposed to different doses of depleted uranium particles through intratracheal instillation. Three months later, morphologic changes and numbers of somatostatin positive cortical and hippocampal neurons were compared. Results： Depleted uranium groups were poorly painted in cortex, and their somatostatin positive cortical neurons were less than those of NS group （P〈0. 05）. Compared with NS group, DU 3 mg and DU 5 mg group were poorly painted in hippocampus, while SS positive hippocampal neurons fell in the 2 groups （P〈0. 05）. Conclusion： Depleted uranium can significantly decrease the number of somatostatin positive neurons in cortex and hippocampus of rats, which may result in brain disability.