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SARS-CoV病毒抗体对恒河猴SARS-CoV的感染保护作用 被引量：1

Protective Effect of Anti-SARS-CoV Antibody on SARS-CoV Infection in Macaca Mulatta
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摘要 目的研究了实验感染产生中和抗体以及输入SARS-CoV中和抗体对SARS-CoV感染恒河猴的保护作用。方法动物分3组,分别为SARS感染恢复动物组,输入抗SARS阳性血清动物组和SARS模型对照组,分别接种病毒,1-7 d进行病毒检测和血清学检测,7 d后安乐处死动物,进行病理检测。结果实验感染产生中和抗体,输入SARS-CoV中和抗体的恒河猴体内SARS-CoV复制得到一定程度的抑制,病理变化也比模型组轻。结论SARS-CoV中和抗体(包括被动免疫)是一种有潜力的SARS治疗方法。 Objective The SARS is an infectious disease which was newly conformed in China. The effective clinical treatment for this disease is still being under studying, The aim of the present study was to investigate the protective effect of antiSARS-CoV antibody on SARS-CoV infection in Macaca mulatta monkey model. Methods To analyze changes of anti-SARS-CoV antibody treated SARS-monkeys. Results The aquired neutralization antibody for SARS-CoV inhibited the replication of the virus to a certain extent. The pathological changes of the antibody treatment group were lighter than those in the SARS-monkey group. Conclusions Our findings suggested that anti-SARA-CoV neutralization antibody therapy is a potentially useful clinical treatment for SARS.
作者 秦川 魏强 高虹 蒋虹 涂新民 邓巍 丛喆 李国生 张连峰 Yasuhiro Yashikawa
机构地区 中国医学科学院中国协和医科大学实验动物研究所 Department of Biomedical Science
出处 《中国比较医学杂志》 CAS 2005年第6期323-326,共4页 Chinese Journal of Comparative Medicine
基金 "863"课题 编号:2003AA2082052003AA208213
关键词 SARS-COV 恒河猴 中和抗体 保护实验 SARS-CoV Rhesus monkey Neutralization antibodies.
分类号 R373 [医药卫生—病原生物学]
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参考文献8

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中国比较医学杂志
2005年 第6期

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